No black and white: Shown are the fascinating shades of individuality. In this artistic representa­

tion, all the variants of a healthy human being (NIH assembly identifier: NA12878) are displayed.

They are organized on several circles, representing the different chromosomes, according to

their position on the chromosome. The size and color of the variants were chosen according to

the severity of the impact on the function of the genome. For example, you can see the many

gray variants that do not fall on any gene and are therefore difficult to classify. This contrasts with

the black and dark variants, which cause a severe defect in the affected genes. This shows how a

considerable number of gene defects can be found even in healthy people as they are compen­

sated by the healthy gene copy from the other parent.